DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

The main regulators of this metabolic shift are the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase (PDK) isoforms 1–4. PDK is known to be overexpressed in several cancers and is ...

Figure 1. Vitamin B1 and B2-mediated immunometabolism in B cell differentiation in the intestine. Vitamin B1 acts as a cofactor for enzymes such as pyruvate dehydrogenase and α-ketoglutarate ...

A mother has told of her heartbreak at losing both her sons to mitochondrial disease, and her attempts to raise awareness of ...

ACTIVATE-Kids is the First Study to Demonstrate Efficacy of an Oral Therapy for Children with PK Deficiency Who Are Not Regularly Transfused –– ...

Artificial photosynthesis technology was developed with the addition of the biocatalyst L-alanine dehydrogenase, which combines ammonia with pyruvate to produce L-alanine, to the photoredox system ...

Agios Pharmaceuticals, Inc. (NASDAQ:AGIO) announced that the ACTIVATE-Kids Phase 3 study of mitapivat in children aged 1 to ...

The intact structure of mammalian multi-enzymatic pyruvate dehydrogenase complex (PDHc) remains poorly understood. Through in-situ structural analysis, the authors unveil its intrinsic dynamics ...

Artificial photosynthesis technology was developed with the addition of the biocatalyst L-alanine dehydrogenase, which combines ammonia with pyruvate to produce L-alanine, to the photoredox system ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Despite promising Phase 3 results, safety concerns, namely liver injury, have impacted Agios stock and could affect Pyrukund's approval and market adoption. Read the full report here.