This included pathways for the citric acid cycle, pyruvate metabolism, cysteine and methionine metabolism, glutathione metabolism, and arginine and proline metabolism. Changes in the rumen microbial ...

The intact structure of mammalian multi-enzymatic pyruvate dehydrogenase complex (PDHc) remains poorly understood. Through in-situ structural analysis, the authors unveil its intrinsic dynamics ...

Despite promising Phase 3 results, safety concerns, namely liver injury, have impacted Agios stock and could affect Pyrukund's approval and market adoption. Read the full report here.

Here the authors show that this decrease in IFN-I production and related pDC functions may be attributed to suppressed oxidative and glycolytic metabolism of pDCs, with lactate dehydrogenase B ...