The identification of protein interactions has been greatly simplified by the invention of yeast-based screening assays such as the yeast two-hybrid system. However, yeast two-hybrid assays cannot ...

作者：哇塞编辑：李宝珠本文已获得沈春华教授授权报道，转载请联系本公众号，并标明来源浙江大学计算机科学与技术学院沈春华教授团队联合澳大利亚阿德莱德大学、美国东北大学等团队，共同提出了一种名为玻尔兹曼对齐的技术，将知识从预训练的逆折叠模型迁移到了 ∆∆G ...

In the human body, proteins form connections with numerous other proteins, creating a complex “interactome” network where ...

Although powerful, microarray chips did not provide any information about the proteins bound to the DNA and how they might affect gene expression. To uncover the sites of protein-DNA interactions at ...

In the pursuit of understanding the pathogenic expression mechanisms of bacteria and the advancements in biofoundry ...

Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and ...

Using a novel geometric deep learning framework, the researchers presented a strategy to create ligand-controlled protein interactions and validated the approach through experiments involving ...

A new study by Weill Cornell Medicine and Oregon Health & Science University sheds light on developing a vaccine to block ...

A new study from The Hospital for Sick Children (SickKids) reveals the process underlying protein organization on cell ...

In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Studying how proteins cluster and organize themselves at the cell membrane could pave the way for innovative cystic fibrosis ...