that improves the study of protein-protein interactions by simplifying detection while improving measurement accuracy. Interactions between proteins play a significant role in biological processes ...

The identification of protein interactions has been greatly simplified by the invention of yeast-based screening assays such as the yeast two-hybrid system. However, yeast two-hybrid assays cannot ...

Using a novel geometric deep learning framework, the researchers presented a strategy to create ligand-controlled protein interactions and validated the approach through experiments involving ...

To uncover the sites of protein-DNA interactions at genome scale, Bing Ren, a former postdoctoral researcher in Young’s lab and now a gene regulation researcher at the University of California, San ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

A new study by Weill Cornell Medicine and Oregon Health & Science University sheds light on developing a vaccine to block ...

A new study from The Hospital for Sick Children (SickKids) reveals the process underlying protein organization on cell ...

In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...

Studying how proteins cluster and organize themselves at the cell membrane could pave the way for innovative cystic fibrosis ...

Figure 2: (a) Schematic plate layout for screening interactions with the GFP reassembly ... 2 ml of wash buffer and then elute His-tagged protein with wash buffer plus 300 mM imidazole.

For decades, scientists have focused on amyloid plaques—abnormal clumps of misfolded proteins that accumulate between neurons ...

Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and ...