that improves the study of protein-protein interactions by simplifying detection while improving measurement accuracy. Interactions between proteins play a significant role in biological processes ...

The identification of protein interactions has been greatly simplified by the invention of yeast-based screening assays such as the yeast two-hybrid system. However, yeast two-hybrid assays cannot ...

To uncover the sites of protein-DNA interactions at genome scale, Bing Ren, a former postdoctoral researcher in Young’s lab and now a gene regulation researcher at the University of California, San ...

Using a novel geometric deep learning framework, the researchers presented a strategy to create ligand-controlled protein interactions and validated the approach through experiments involving ...

We also collaborate on various structural biology projects with local bioscience research groups with interest in structural studies in particular through the protein crystallography core facility.

A new study from The Hospital for Sick Children (SickKids) reveals the process underlying protein organization on cell ...

In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...

A recent study by Chinese scientists has revealed the intricate molecular machinery driving energy exchange within ...

Figure 2: (a) Schematic plate layout for screening interactions with the GFP reassembly ... 2 ml of wash buffer and then elute His-tagged protein with wash buffer plus 300 mM imidazole.

Studying how proteins cluster and organize themselves at the cell membrane could pave the way for innovative cystic fibrosis ...

For decades, scientists have focused on amyloid plaques—abnormal clumps of misfolded proteins that accumulate between neurons ...

Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and ...