Abnormal proteins involved in mitochondrial bioenergetics, dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance have been linked to the pathogenesis of a number of ...

Neurofilament proteins (NfPs) are well suited as biomarkers in these contexts because ... Biochemical, genetic, and animal model evidence implicates NfPs as a pathogenic culprit playing primary or ...

Simplified redesign of proteins to improve ligand binding Date: January 21, 2025 Source: University of Alabama at Birmingham Summary: The ability to alter proteins to refine control over binding ...

A single drop of blood might be able to predict the onset of dozens of diseases, a new study claims. Analysis of the protein "signatures" in a droplet of blood can predict 67 diseases, including ...

Moreover, protein ... to treat diseases. While the idea of a chain of amino acids folding into a working protein might seem simple, it’s a finely tuned process. The folded structure is what ...

It has been a few years since AI began successfully tackling the challenge of predicting the three-dimensional structure of proteins ... Right now, the primary treatment is to use a mix of ...

are a family of proteins that play crucial roles in the metabolism of fatty acids and the regulation of various metabolic disorders. Among these, adipocyte fatty acid-binding protein 4 (FABP4 ...

However, in many cases, it's not entirely clear how these mutations affect the structure ... to cause diseases in humans. They found that 60% of these mutations made affected proteins less stable.

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves ...

Researchers from Mainz University and EMBL Hamburg present a new approach for structurally characterising disordered proteins ...

New research highlights BCL6 protein’s role in preventing muscle loss during GLP-1 medication use, offering hope for ...