The single polypeptide chain is folded into three parts, with the active site at their conjunction. In the active enzyme, the side chain of His 64 is in a position consistent with the formation of ...
J. Frydman, E. Nimmesgern, K. Ohtsuka, F.U. Hartl, "Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones," Nature, 370:111-7, 1994. (Cited in nearly 50 ...
This linkage is known as a peptide linkage. (ii) Primary structure: It is a specific sequence of linkages between amino acids in a polypeptide chain. Different sequences are present in different ...
Specifically, we introduce R-Chain, which is based on a chain structure to build related metapath instances together. We can efficiently reuse vertices through R-Chain and process different R-Chains ...
Synthesised as a single chain polypeptide (molecular weight of 150 kDa), botulinum toxin has relatively little potency until it is cleaved by trypsin or bacterial enzymes into a heavy chain (100 kDa) ...
A polypeptide is ... While the idea of a chain of amino acids folding into a working protein might seem simple, it’s a finely tuned process. The folded structure is what allows proteins to ...
Our approach views GVCs as exchange networks, and relies on the Leontief Decomposition method to summarize the network structure and relationships by incorporating direct and higher-order value added ...