Windtree Therapeutics, Inc. (NasdaqCM: WINT) showcased encouraging results from the Phase 2b SEISMiC study of istaroxime, its novel investigational therapy for early cardiogenic shock, at the ...

The heart drug digoxin could potentially be combined with existing cancer therapies to prevent the spread of tumors, an early ...

HSP90 inhibitors have also been shown to induce apoptosis by indirectly inhibiting Akt. The FDA-approved cardiac glycoside drugs digoxin, digitoxin, and ouabain can mediate the elimination of ...

encouraging larger follow-up studies with refined Na+/K+ ATPase inhibitors and that include clinical outcome endpoints.” Certain tumor types do not remain at their point of origin but spread ...

The study design comprised measuring the effect of the cardiotonic agent digoxin (a widely used Na+/K+ ATPase inhibitor) in reducing the size of circulating tumor cells clusters, i.e. aggregates ...

On the other hand, the integrity of RPE cells is also closely related to the electrical activity of the cell membrane. Na+/k+-ATPase is an essential source of energy for RPE cells. It uses the energy ...

After more than 20 years of intensive research the molecular machinery of Resurgent Currents (INaR), a non-canonical identity of currents mediated by voltage-activated sodium channels is still a ...

Evolution of F- and V-type ATPases The central stalk of the F- and V-type ATPase molecular machine is essential for rotation catalysis, and so the distinct lack of conservation between the F- and ...