Plant cells form acentrosomal spindles with microtubules (MTs) converged toward two structurally undefined poles by employing MT minus end-directed Kinesin-14 motors. To date, it is unclear whether ...

indicated with cerulean arrows), peripheral doublet microtubules (DMTs, indicated with orange arrows), inner dynein arms (IDAs, indicated with green arrows) and outer dynein arms (ODAs, indicated with ...

In humans, microtubules are composed of various tubulin isoforms:α-tubulin, β-tubulin, γ-tubulin, δ-, ϵ-, and z- tubulin (33). The heterodimers of α- and β-tubulin are the basic structural components ...

However, a successful therapy has not yet been found, partly because the molecular pathogenesis is largely elusive. Here we show that KIF12 kinesin suppresses MASH development by accelerating the ...

The authors show experimentally that the said mutation disrupts the proper axonemal arrangement and recruitment of DNALI1 and DNAH1 - proteins of inner dynein arms. Based on these results, the authors ...

Our laboratory studies kinesin and dynein, the two types of motors that move along microtubule tracks. The mechanism of kinesin is reasonably well understood through measurements of its single ...

Image credit: Andrew Kennard (University of Massachusetts, Amherst). The long tail of a sperm cell, the finger-like cilia in the lungs, and the long axons of nerves are all built with ...

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Particularly, we are interested in how the distinct motors myosin, dynein and kinesin coordinate to transfer the endosome smoothly from the actin to the microtubule network, ensuring precise ...

Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States Wallace H. Coulter Department of ...