Discover 8 ways mast cell activation syndrome causes widespread symptoms from digestive issues to brain fog, often mistaken ...

Mast cell activation syndrome (MCAS) is a condition in which mast cells—a type of white blood cell that plays a key role in ...

The following is a summary of “Novel Bradykinin Detection In The Diagnostic Workup Of Patients With Recurrent Angioedema ...

Mast Cell Activation Syndrome (MCAS) is a condition where cells in the body's immune system release too much histamine, ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

but erroneous activation of mast cells also triggers allergic reactions, including swelling, hives, itching and, in severe cases, anaphylaxis. In a previous Cell paper, Kaplan and his team found ...

At the recent AAAAI/WAO meeting, Blueprint Medicines Corp. presented the in vitro and in vivo characterization of BLU-808, a selective inhibitor of wild-type KIT, a transmembrane receptor tyrosine ...

Caroline Cray was diagnosed with mast cell activation syndrome in May 2019 after repeated anaphylactic episodes Jordan Greene is Society and Culture writer-reporter at PEOPLE. She has been working ...

with emerging strategies focusing on reducing mast cell numbers, inhibiting activation pathways, and suppressing degranulation. 1,5 Patients with CSU often face diagnostic delays, as symptoms may ...

In addition to mast cell activation symptoms, advanced SM is associated with organ damage due to mast cell infiltration and poor survival. AYVAKIT (avapritinib) is approved by the U.S. Food and ...

Allergic inflammation plays a big role in allergy reactions and contributes to the itching and chewing commonly seen with ...

The paradigm of stellate cell activation provides an important framework for defining therapeutic targets. Hepatic fibrosis is a wound healing response comprising reversible scarring that occurs ...