Schematic presentation of hepatic stellate cells (HSC) located in the vicinity of adjacent hepatocytes (PC) beneath the sinusoidal endothelial cells (EC). S - liver sinusoids; KC - Kupffer cells.

The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal ... abundant cell type in liver, are a potent source ...

Rerouting of portal blood to the sinusoids was accomplished by excision of the involved liver in the right lobe and by occlusion of the left branch of the portal vein. This was accompanied by an ...

In the liver, senescence impacts key cell types including hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells, and contributes to chronic liver diseases such as fibrosis ...

Thus, there is sinusoidal congestion, liver cell loss, and fibrosis, with all three predominating in the centrilobular areas. 3,4 Secondary thrombosis due to vasculitis is rare, as is invasion or ...