The hypothetical alternative pathways outlined above illustrate the potential competition for various isomeric pentadienyl and peroxyeicosatetraenoyl radical intermediates that may be crucial for a ...

Bacteria control the homeostasis of membrane lipid biophysical properties by altering the chain length of fatty acids, as well as the ratio of saturated:unsaturated fatty acids. The de novo ...

Traditional approaches can take years to generate an effective lipid, but the team's guided evolution process may shorten that time to a matter of weeks or months. Our hope is that this method ...

“Evolution isn't just a story about where we came from. It's an epic at the center of life itself.”– Kenneth R. Miller, Biologist, Brown University If you are reading this sentence, you’re ...

While it can take years to develop an effective lipid using traditional methods, the team's directed evolution process could reduce this timeline to just months or even weeks. "Our hope is that ...

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials , 2025; DOI: 10.1038/s41563-024-02114-5 Cite This Page : ...

A lipid nanoparticle system has been developed to deliver mRNA across the blood-brain barrier via intravenous injection, overcoming a significant challenge in treating brain diseases.