A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Baylor, together with Rice University, offers extensive resources dedicated to the molecular and phenotypic characterization of mouse models through its hosting of its Center for Precision Medicine ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

They developed a novel Tle6 gene hetero knockout male mouse model using a technique called CRISPR-Cas9 that enables the editing of genes. Their findings were published in the journal Frontiers in ...