Despite promising Phase 3 results, safety concerns, namely liver injury, have impacted Agios stock and could affect Pyrukund's approval and market adoption. Read the full report here.

Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. IDH exists in three different isoforms, whose mutation ...

Known enzymes involved in this process include malic enzyme, glucose-6-phosphate dehydrogenase and 6-phosphogluconic dehydrogenase from the phosphate pentose pathway and isocitrate dehydrogenase (Hao ...