Ion channels are integral membrane protein assemblies that modulate the flow of ions into and out of a cell or organelle, leading to generation of electrical signals. Opening (gating) of ion ...

Our study also includes canonical ion channel blockers, such as tetrodotoxin and saxitoxin, small molecules whose structures have been resolved for drug discovery campaigns, such as GX-936, Z944, and ...

Therapeutic benefits of TRPV4 inhibition have, therefore, to be carefully weighed against potential adverse ... permeability or the hemodynamic response associated with hypoxemia and HAPE (4). Recent ...

Pharmacological or genetic inhibition of acid-sensing ion channel 3 impeded the development of LPC16:0-induced chronic hyperalgesia. Darapladib and antioxidants could effectively alleviate the ...

The toxic bite of a Gila monster can kill a human, but a specific ingredient in the cocktail of the lizard's venom is the ...

Jazz Pharmaceuticals has agreed another pipeline-building deal, this time paying $10 million upfront for rights to a KRAS inhibitor programme from UK biotech Redx Pharma, continuing a move into ...

Inhibition of Wnt/β-catenin signalling has therefore been proposed as a therapeutic ... HAMLET suppresses β-catenin-dependent transcription. The effects of HAMLET were ion channel-dependent, defining ...

The drugs most frequently used by these patients were diuretics, converting enzyme inhibitors, calcium channel blockers (CCB), lipid-lowering agents, and salicylates. Eczema was significantly ...

New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D.

A conserved intracellular loop 1 (ICL1) bridges cytosolic regulatory domains and the ion translocation path via simultaneous interactions with the NTD and intracellular gate region. The NKCC1 CTD ...

drowsiness or dizziness Angiotensin II receptor blockers These may be used to treat heart failure or after a heart attack. dizziness, headache, fatigue, and others Calcium channel blockers These ...