In its role in recruitment of histone methyltransferase activity, it can act as a tumor suppressor by activating transcription of antiproliferative target genes, such as those encoding a cyclin ...

Histone modifications play an essential role in macrophage functions. Here, we report that Cxxc finger protein 1 (CFP1), a key component of the SETD1 histone methyltransferase complex, promoted the ...

2013) and epigenetic modulators (Nassa et al., 2019b) that drive gene expression changes underlying BC development and progression. The histone H3 lysine 79 methyltransferase disruptor of telomeric ...

The most popular of these treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation can reactivate genes that have been silenced. Two examples of these ...

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The transmission of epigenetic modifications (e.g., DNA methylation, histone modifications, non-coding RNAs) across generations, shaping offspring phenotype without altering the DNA sequence. The ...