To investigate the influence of DNA damage regulators on the acetylation of histone H3 and gene transcription, U2OS cells expressing SNAP-labeled H3.1 or SNAP-labeled H3.3 were treated with ATM, ATR, ...

Previous studies have shown that neuronal histone acetylation is reduced in mouse models of RSTS. Conclusions The authors' results extend to humans the seminal observations in RSTS mouse models and ...

Methods FLS were purified from patients with RA and CD14 + human monocyte-derived macrophages were obtained from healthy donors. RNA-sequencing, histone 3 lysine 27 acetylation (H3K27ac), chromatin ...

The field encapsulates modifications made directly to DNA and post-translational modification of histones. In this study, we will explore DNA methylation and histone acetylation, in the context of ECM ...

The best-studied chromatin modification is histone acetylation, which is correlated with activation of gene transcription. By contrast, histone deacetylation (mediated, for example, by complexes ...

The authors suggested that DNA methylation, histone acetylation, and/or non-coding RNAs were likely avenues of transgenerational inheritance, although these avenues were not explored in the study (22) ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Examples include DNA methylation and histone acetylation, which can turn genes on or off. Despite their differences, both mechanisms contribute to molecular aging. Researchers have long speculated ...

Histone acetylation, transcription factor dynamics contribute to gene expression in brain development Dec 27, 2023 Blocking key protein may halt progression of Alzheimer's disease ...

Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518000, China ...