Hepatotoxicity is damage or injury to the liver as a result of damaging or destructive agents such as drugs or industrial chemicals which are termed hepatotoxins. This study reveals that ...

Researchers have demonstrated, for the first time in the world using mice, the ability to overcome significant challenges in ...

†Data from lapatanib-treated patients with metastatic breast cancer [43,93]. ‡Data from pazopanib-treated patients with renal cell carcinoma [31]. §This is a definition of a possible Hy's law ...

Taken together, PMI’s preclinical and clinical data constitute a concerning pattern of possible hepatotoxicity, especially considering the short period of exposure. These findings indicate IQOS may ...

Company completed Type C meeting with FDA, aligning on its plan to submit an sNDA; submission expected around end of 1Q25If approved, FILSPARI ...

was performed to explore the molecular mechanism of arsenic-induced apoptosis and the protective effect of DIP on arsenic-induced hepatotoxicity. Food-grade Dictyophora was provided by Zhijin Sifang ...

Subsequently, its potential protective effect against hepatotoxicity induced by valproic acid (VPA) was investigated in Wistar rats, both as preventive and curative treatments. For this purpose, two ...

The Food and Drug Administration (FDA) has approved Romvimza ™ (vimseltinib) for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will ...

The hepatotoxicity of PM 2.5 Over the past 20 years, mortality due to air pollution has continued to rise, with over 6.7 ...

Ono picked up Romvimza—previously known by its active ingredient vimseltinib—from its $2.4 billion acquisition of Deciphera ...

Perhexiline is an antianginal medication used in refractory disease. Despite being highly efficacious, it is seldom prescribed due to its risk of neurotoxicity and hepatotoxicity. These adverse ...