Background: Biopsy is the usual gold standard for liver steatosis assessment. The aim of this study was to identify a panel of biomarkers (SteatoTest), with sufficient predictive values ...

Our data showed that oleic acid induce oxidative damage and steatosis in hepatocytes both in vitro and in vivo, and activate the PPARγ/NF-κB p65 signal pathway. Moreover, isoorientin can significantly ...

The authors developed multicellular organoids with hepatocyte, stellate, and Kupffer analogs, which in response to free fatty acid treatment show signs of steatohepatitis, including steatosis, ...

[54] NASH is presumed to develop as a consequence of a 'second' or 'multiple hits' on the steatotic hepatocytes. The first hit results from a number of pathways leading to hepatic steatosis.

The discovery that RIPK1 deficiency sensitizes the liver to acute injury and hepatocyte apoptosis is based on convincing evidence ... For histopathology, frozen sections of liver tissues were stained ...

Hepatic inflammatory infiltration, hepatocyte lipid accumulation and overall survival were assessed as primary ... Blocking CXCR1/2 receptors increases survival in a murine model of alcoholic liver ...

Our mission is to provide a state-of-the-art facility, expertise, and education in advanced quantitative light microscopy to support Drexel University’s research community The Cell Imaging Center (CIC ...

Pretreatment with the multityrosine kinase inhibitor sorafenib did not affect autophagy impairment and steatosis but significantly reduced ERK phosphorylation and inflammatory response in ...

Patients with metabolic dysfunction-associated steotohepatitis (MASH) who are already taking a glucagon-like peptide-1 receptor agonist (GLP-1RA) could see their liver health improve with the addition ...

Hans Clevers 研究团队利用类器官技术解锁胰腺再生新篇章！刊发在《Cell》（IF：45.5）的最新研究论文[1]显示，科学家通过类器官和单细胞基因测序等技术，发现人类胎儿胰腺中的LGR5+干细胞群，并开发了一种能够在体外长期扩增并具备分化潜力的类器官系统，首次实现了人类胰腺三种主要细胞类型的体外生成。该研究为揭示胰腺疾病发育机制，开发治疗胰腺炎、糖尿病等胰腺相关疾病新药提供了新策略。