During fibrosis, (myo)fibroblasts deposit large amounts of extracellular matrix proteins, thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of hepatocyte function, ...

Figure 1: a, Schedule of DMN administrations and HGF–HVJ liposome or PBS injections. Figure 3: a–c, Liver sections of rats after DMN administration. Sprague–Dawley rats 4–5 weeks old and ...

Viral infections are a predominant cause of liver disease around the world, impacting millions with conditions ranging from mild inflammation to severe ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty acids, and nucleotides. To date, ...

By injecting modified si-RNAs, they demonstrated that Lhx2 knockdown impaired hepatocyte proliferation and liver function recovery after acute injury. Additionally, using Lrat-cre (HSC-specific ...

The review aims to explore how these transporters influence the pathophysiological processes underlying liver diseases, focusing on their roles in lipid metabolism, hepatocyte function, and the ...