Farnesyl diphosphate synthase (FPPS) is a key enzyme in this ... of key enzymes in the mevalonate pathway, including HMG-CoA reductase (HMGR) and MK. Understanding the structural basis of these ...

HMG CoA is then converted to mevalonate via HMG-CoA reductase ... where it is converted to either glucosylceramide on the cytosolic side of the Golgi via glucosylceramide synthase, or to sphingomyelin ...

MANILA, Philippines — The Commission on Audit (COA) has called out the Philippine Atmospheric, Geophysical and Astronomical Services Administration (PAGASA) over P256.07 million worth of ...

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The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving mediators, in the regulation of inflammation is well established. While the ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...