The man’s case didn’t give rise to any widespread variant, but it gave Gupta, with his HIV evolution background, the idea ...

To become infectious, HIV has to undergo a maturation process, which involves a rearrangement of the matrix proteins (red). In an immature virus particle, the matrix proteins form a lose lattice ...

An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...

What about viruses? Would you consider them living or nonliving? Let’s look closely at the life cycle of the human immunodeficiency virus (HIV) – the virus that causes AIDS – to find out. This ...

After entering an immune cell, HIV's single-stranded RNA genome is reverse-transcribed into double-stranded DNA, which is how our cells store genetic information. The virus' genome is incorporated ...

“The HIV genome is very small, so to replicate itself, it hijacks all sorts of cellular machinery. nSMase2 is one piece of this hijacked machinery that we found is absolutely essential for HIV to ...

Although several human genetic variants have been implicated in the control and spread of HIV within a host, this is the first time that a sex chromosome has been found to harbor a suspect stretch of ...

In August 23 Cell, Astrid Schröder and colleagues at The Salk Institute, La Jolla, California show that HIV-1 chooses active genes and local hotspots for integration in the human genome (Cell 2002, ...

Transposons, also known as jumping genes or mobile genetic elements as they can replicate and reinsert themselves in the ...

One of the significant challenges in HIV treatment is the virus's ability to integrate its genome into the host's DNA, making ...

HIV-1 Vif induces a unique and prolonged pseudo-metaphase arrest by disrupting phosphatase feedback regulation at the kinetochore.