Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most ...

Mass General Brigham researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery ...

PK/PD analyses of circulating tumor DNA (ctDNA) in patients with metastatic colorectal cancer (mCRC) treated with telisotuzumab adizutecan (ABBV-400). This is an ASCO Meeting Abstract from the 2025 ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China ...

Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammation Half of the psoriasis patients in the study had increased intestinal barrier permeability or leaky gut.

These cells were found to promote airway inflammation through the characteristic effector molecule Granzyme K (GZMK), which is a serine protease involved in inflammatory pathway activation.

Accordingly, the researchers engineered cyclic peptides—small amino acid chains—to respond only when they encounter two specific types of enzymes, proteases called granzyme B (secreted by the ...

This patent application pertains to macrocyclic peptides and their radiolabeled derivatives, generally represented by Formula I. These compounds exhibit selective binding to Granzyme B (GzmB) and hold ...