Nature5y
Gene targeting with recombinant adenoviral vectors
A nonfunctional mutant of a reporter gene (W in the figure) is introduced or is present in a cell (a). In the recombinant targeting vector (b), the viral genes are replaced by a sequence that is ...
Nature1y
Vagaries of conditional gene targeting
Conditional gene targeting based on excision or inversion of loxP-flanked DNA segments by Cre recombinase is a powerful technology for the analysis of gene function, but unexpected expression ...
Hosted on MSN5d
USC receives grant for gene therapy targeting glioblastoma
The University of Southern California (USC) has received a $6m grant from the California Institute for Regenerative Medicine ...
News Medical on MSN6d
New grant funds first-of-its-kind gene therapy to treat aggressive brain cancer
The California Institute for Regenerative Medicine has awarded a $6 million grant to USC investigators pioneering a new first-of-its-kind genetic therapy for glioblastoma, a severe form of brain ...
Mutations in two gene pairs point to a promising drug target in 5% of adult cancers
Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have ...
Science Daily16d
Targeting potassium channel shows promise for treating brain tumors
Researchers find blocking the KCNB2 gene can slow tumor growth, paving the way for next-gen treatments for childhood brain cancer.
Hosted on MSN1mon
Targeting Cancer with Nanoparticle-Delivered Gene Therapy
Liu created the particles that were utilized to precisely deliver the gene therapy to cancer cells ... a cancer-specific promoter and a cancer-targeting nanoparticle, we found this therapy ...