研究人员为解决 Cre-loxP 单质粒合成难题，开展 TAx9 相关研究，成功创建 F0 代转基因动物，意义重大。 开启基因编辑新征程：TAx9 技术的诞生 在生命科学的奇妙世界里，基因编辑技术宛如一把神奇的 “剪刀”，帮助科学家们探索生命的奥秘。其中，Cre-loxP 系统 ...

In vivo treatment achieves genome editing and restores mice vision. Synthesis of one-step Cre-loxP integrated plasmids is enabled by inclusion of a short “TAx9” DNA sequence during cloning ...

D. Regenerated Liver to pre-hepatectomy body weight ratio of the mice in B. F. Quantitation of nuclear counts per field (76,000 um2). Six images were taken for each liver. 0 hr (pre- resection). 42 hr ...

Mar. 10, 2025 — The herb rosemary has long been linked with memory: 'There's rosemary, that's for remembrance,' says Ophelia in Shakespeare's Hamlet. So it is fitting that researchers would ...

Here, using a spontaneous remyelination model in mice, we found that retinaldehyde dehydrogenase 2 (Raldh2), a rate-limiting enzyme for retinoic acid (RA) synthesis, is upregulated in OPCs and in a ...

They compare this time course with the last few years of Cre-LoxP-based tracing studies and they make an assumption that most hematopoiesis ... Understanding the clonal output of HSPCs in aged mice in ...

The University of Georgia has been at the forefront of research utilizing transgenic mice. These genetically modified mice are valuable in studying human diseases due to their genetic similarity ...

The mice used in the study were adult (8–15 weeks) CRH-ires-Cre knock-in mice (Stock No. 012704) (Jackson Laboratory, Bar Harbor, ME) and C57BL/6 mice (N/A) (Shanghai Model Organisms). One week after ...

Hepatocyte-restricted PPARα deletion is sufficient to promote NAFLD and hypercholesterolaemia during ageing, but does not lead mice to become overweight. Here we investigated consequences of ...