Aim: We evaluated a novel treatment for obesity-related renal, an ATP-citrate lyase (ACL) inhibitor ... could decrease the levels of serum lipid and renal lipogenic enzymes acetyl-CoA carboxylase (ACC ...

In eukaryotes, PUFAs can be de novo synthesized through two independent biosynthetic pathways: the desaturase/elongase pathway and the PUFA synthase pathway. Among them, PUFAs synthesized through the ...

Many individuals turn to magnesium supplements to meet their requirements and boost their health. Magnesium glycinate and citrate are two common forms of magnesium supplements that are generally ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Feb. 12, 2025 — Scientists have uncovered the equipment that enables bacteria to survive exposure to antibiotics: a shuttling mechanism that helps a complex of proteins pump out a wide spectrum ...

The crystal structure of pseudouridine synthase I from Escherichia coli, which, for example, modifies positions 38, 39 and/or 40 in tRNA, reveals a dimeric protein that contains two positively ...

AI molecular design tool for de novo design, scaffold hopping, R-group replacement, linker design and molecule optimization.

With the approval of the soluble guanylate cyclase stimulator riociguat, an additional drug class has become available targeting a distinct molecular target in the same pathway as PDE5 inhibitors.

Here, using a broad set of in vivo and in vitro measurements using purified enzymes, we find that leucinostatin A, but not lefleuganan, specifically targets the mitochondrial ATP synthase, inhibiting ...

An artificial intelligence model has created a new protein that researchers say would have taken 500 million years to evolve in nature — if nature were capable of producing such a thing.

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Developing a cyclic molecule that captures phosphate in harmony with water molecules Dec 5, 2024 Metal-organic framework materials to remove dye contaminants for cleaner water ...