The eccDNAs currently studied in this paper are mainly large, copy number–amplified extrachromosomal circular DNA. EccDNAs are widely present in human tumor tissues and tumor cell lines, where they ...

Researchers say if their results are confirmed through further study they are optimistic the approach could be used to treat chronic infections for the first time.

Hirt covalently closed circular DNA extraction and Taq-man probe qRT–PCR For HBV cccDNA extraction, we used the previously described modified Hirt method (Cheng et al., 2021). In brief, the cells were ...

Cancer cells store genes in circular pieces of DNA, known as extrachromosomal DNA or ecDNA, that defy the laws of genetics.

Scientists from Flinders University in Australia have made a surprising discovery about a recently identified type of genetic material called circular RNAs. Their research suggests that these ...

Recent research reveals that DNA and RNA epigenetics, previously studied as independent systems, actually function as a complementary regulatory network. This dual mechanism enables precise gene ...

Serum HBV RNA levels quantified by using a new automated prototype assay significantly correlated with intrahepatic covalently closed circular DNA (cccDNA ... In HBeAg(−) patients, the predominant ...

RNA levels and included in detailed models. Protein levels and DNA-binding were validated, using NanoLUC reporters in vivo, ...

15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.