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张锋最新论文:开发最小化免疫原性的CRISPR核酸酶,为更安全的基因 ...
该研究对用于 CRISPR 基因编辑治疗的 Cas 核酸酶 SaCas9 和 AsCas12a 进行了理性工程化改造,设计出了具有最小化免疫原性的 SaCas9 和 AsCas12a 突变体。
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