"When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8 + T cells," Grimson said. Meanwhile, in Hanson's lab ...

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

These receptors allow T cells to sense and respond to diverse types of infection. CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to ...

Researchers explore the cellular and molecular adaptations associated with human secondary lymphoid tissue in adults during ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme—P4HA1 prolyl hydroxylase, is strongly induced in CD8 + T cells in solid cancer, the primary ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme – P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary ...

More information: Joanne D. Tejero et al, Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells ...

在Nature Cancer期刊以长文的形式发表了题为“ETV7 limits the antiviral and anti-tumor efficacy of CD8+ T cells by diverting their fate towards exhaustion （ETV7通过促进CD8+ T细胞命运向耗竭的转化，限制CD8+ T细胞抗病毒和 ...