Central to the pathogenesis of VaD are cerebrovascular endothelial cell (CEC) dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation. CD38, an enzyme involved in neuroinflammation ...
Background CD38 is a NAD+ consuming enzyme ubiquitously expressed on immune cells and its expression increases in several pathological conditions, including Rheumatoid Arthritis (RA) [1, 2].
charite.de We recently reported the successful treatment of two systemic lupus erythematosus (SLE) patients with daratumumab, a CD38-targeting human monoclonal antibody, demonstrating a clinically ...
U.S.-based biotech builder Mountainfield Venture Partners and China’s Keymed Biosciences have launched a new company armed with $180 million in series A funds and a clinical-stage CD38-targeting ...