The model organism Caenorhabditis elegans has proved invaluable for the study of proteostasis in the context of aging, longevity and disease, with a number of pivotal discoveries attributable to the ...

Comparison of anatomy for mammalian and discussed non-mammalian vertebrates ... To succeed, the model must also be supported by an enthusiastic and invested community. For example, C. elegans, ...

Blots were probed with Expresshyb buffer (Clontech) following manufacturer's specifications (final wash, 0.1× SSC and 0.1% SDS at 50°C). Immunofluorescence, protein extractions and western blots ...

For example, the most extensively studied methylation is that of the fifth carbon of the cytosine's pyrimidine ring—a potentially mutagenic event that frequently causes C:G to T:A transitions.