Novartis has joined with Allergan in a bid to get ahead in the race to get a drug approved to treat the fatty liver disease, non-alcoholic steatohepatitis (NASH). The Swiss pharma said it is to ...

The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in intestinal antibacterial defence ... Methods Colitis was induced in wild-type (WT) and Fxr-null mice using dextran sodium ...

Proinflammatory cytokines stimulate glucocorticoid (GC) release by adrenals but they also inhibit bile acid (BA) efflux from liver. Chronic hepatic inflammation leads to cholestasis and impaired GC ...

Antibodies for ERK (clone 137F5), phosphor-ERK (clone D13.14.4E), AKT (clone 40D4), phospho-AKT (clone D9E), FXR (clone E4B8P), and Actin (clone E4D9Z ... expression while the PI3K/AKT pathway only ...

Expert Rev Cardiovasc Ther. 2008;6(3):391-409. Phosphatidic acid phosphatase/phosphohydrolase (PAP) is an enzyme that catalyzes the conversion of phosphatidic acid to ...

Pantothenic acid (vitamin B5), a water-soluble B vitamin, is sometimes called the "anti-stress vitamin." It is required for the body to make coenzyme A (CoA). CoA is involved in many reactions, such ...