However, there is still a big gap in knowledge about the association between gut microbiota associated metabolism alterations and GDM development ... sequencing and high-performance liquid ...

Our gut is a bustling hub of activity, home to trillions of microbes that work together with our bodies to keep us healthy. A recent study explores one fascinating aspect of this partnership: how gut ...

Synthesized in the liver, bile acids play diverse roles in digestion and metabolism. However, when their processes are disrupted, disease can occur. Scientists seek advanced technologies to better ...

This helps improve fat metabolism by aiding in the breakdown and processing of fat. When gut bacteria produce large amounts of bile acids that activate FXR and reduce bile production, the body ...

While studying mouse and human liver tumors, they discovered that certain bile acids in the liver could affect the activity of cancer-fighting immune cells, called T cells. The researchers ...

本研究表明，阿来昔诺在治疗 MASH 和相关 HCC 方面具有显著疗效。它能够改善脂质代谢，减轻肝脂肪变性，调节胆汁酸代谢，增加胆汁酸合成和排泄，同时减少肠道重吸收。阿来昔诺还改变了肠道微生物群的组成，增加了阿克曼菌的丰度，且微生物群与胆汁酸代谢之间存在密切关联。此外，阿来昔诺减轻了 MASH 相关的炎症、肝损伤和纤维化，有效预防了 MASH 进展为 HCC。 目前针对 MASH ...

They do all this by binding to a receptor called FXR, which acts like a traffic light, controlling cholesterol metabolism and bile acid production to avoid excess buildup." Here's where the ...

They found that those who lost protection also had generally higher levels of bile acids. However, those with remission had higher levels of two specific bile acids, known as lithocholates.

Bile acid metabolism was investigated in 10 patients after cholecystectomy, 10 gallstone patients, and 10 control subjects. Diurnal variations of serum levels of cholic and chenodeoxycholic acid ...