本研究表明，阿来昔诺在治疗 MASH 和相关 HCC 方面具有显著疗效。它能够改善脂质代谢，减轻肝脂肪变性，调节胆汁酸代谢，增加胆汁酸合成和排泄，同时减少肠道重吸收。阿来昔诺还改变了肠道微生物群的组成，增加了阿克曼菌的丰度，且微生物群与胆汁酸代谢之间存在密切关联。此外，阿来昔诺减轻了 MASH 相关的炎症、肝损伤和纤维化，有效预防了 MASH 进展为 HCC。 目前针对 MASH ...

FGF19 negatively regulates bile acid synthesis and recombinant FGF19 increases the metabolic rate of mice. Unfortunately, FGF19 transgenic mice develop hepatocellular carcinomas, and this side ...

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory for Digestive Health, National Clinical Research Center for Digestive Disease, Beijing ...

Be it on a toast or on a plain paratha, butter is an integral part of every Indian diet- traditional and modern, both.

Fat metabolism is a fascinating process and essential for human survival. It involves the digestion, absorption, transportation and utilization of lipids as a source of energy or as an energy reserve.

Dec. 16, 2024 — Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified ...

Announcing a new article publication for BIO Integration journal.   Diabetes, a common metabolic condition, poses a substantial health burden worldwide. To revolutionize diabetes management, enhance ...

Biosynthesis is the generation of natural products through enzymatic reactions, as in cellular metabolism. Successive enzymatic reactions by a number of enzymes are generally required to achieve a ...

After experiencing an uptick in gut inflammation, one writer finds her 30s to be a wake-up call for prioritizing digestive ...

The liver is generally referred to as the detox powerhouse of the body. Its role in general health is so important that it ...