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生物谷
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Nature Medicine:抗癌战场迎来"智能导弹"!B7H3靶向药物改写晚期实体瘤 ...
当ADC被肿瘤细胞内吞后,连接子在溶酶体酸性环境(pH 4.5-5.0)中完全断裂,释放全部载荷。这种"内外夹击"策略使药物利用率提升3倍以上(临床前数据显示肿瘤内药物浓度达传统ADC的2.8倍)。
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