Objectives Non-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in aortic stenosis. We assessed aortic valve calcific and non-calcific disease using ...

Methods In 149 patients (104 mild AS, 36 moderate AS and 9 severe AS) enrolled in 2 ongoing prospective cohorts (COFRASA/GENERAC), we evaluated AS haemodynamic severity at baseline and yearly, ...

[11–14] Calcific aortic valve disease is characterized by progressive aortic valve leaflet thickening and calcification that ... most commonly using CT angiography, to document the extent ...

Bicuspid aortic valve disease occurs when individuals are born with a deformed valve, which, unlike the normal heart valve, starts to calcify at an unusually early age. Normally, heart valve ...

Calcific aortic valve disease is the pathological remodeling of valve ... we investigated whether TERT contributes to the osteogenic reprogramming of valve interstitial cells. TERT’s noncanonical ...

The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes ...

We determined the association of atherosclerotic calcification in the aortic arch, as proxy for systemic atherosclerosis ... Non-calcified parts of the plaques cannot be visualized with non-enhanced ...

Background Current guidelines recommend transcatheter aortic valve implantation (TAVI ... PA diagnosis was made when non-contrast axial CT images fulfilled Valve Academic Research Consortium-2 ...

The researchers reviewed data on nearly 110,000 patients who underwent surgical replacement of aortic valves between the ages of 40 and 79. They found that in those aged 60 or younger, mechanical ...

Using hormone replacement therapy (HRT) to reduce cardiovascular risk during menopause remains a topic of debate. The ...

Researchers used whole genome microarray genotyping on 272 bicuspid aortic valve patients with early onset valve or aortic disease and 272 biological relatives. They analyzed all copy number ...