Protein homeostasis is the process by which cells ... a primary factor in protein misfolding and aging. The ER is responsible for protein synthesis and folding; however, when overwhelmed by ...

offering hope for a future of healthy aging. As we age, the intricate balance of protein homeostasis (proteostasis) — the system responsible for maintaining cellular health by ensuring proteins ...

Protein homeostasis plays a central role in the proper ... a factor contributing to aging. By studying C. elegans worms, they observed that MANF helps eliminate abnormal proteins that accumulate ...

offering hope for a future of healthy aging. As we age, the intricate balance of protein homeostasis (proteostasis) - the system responsible for maintaining cellular health by ensuring proteins ...

the collapse of protein homeostasis in the cell. For example, the polyglutamine repeat in Huntington's disease can tip an aging cell, struggling to maintain homeostasis, into a cascade of misfolding.

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Protein homeostasis refers to regulating the functionality of every individual protein in the proteome. Proteins prone to misfolding present a particular challenge to cellular protein homeostasis and ...