Targeting the SLC25A1-ACLY axis is therefore a potential therapeutic strategy for ferroptosis-targeted cancer intervention. Ferroptosis is an iron-dependent form of programmed cell death that is ...

A series of assays were conducted to examine the effects of ACLY on the proliferation and migration of CCA cells. Ferroptosis inducers and inhibitors, along with lipid peroxide probes and MDA assay ...

SLC13A2 increased cleavage of SREBP2, and expression of cholesterol metabolism genes, including LDLR and HMGCR. Mechanistically, SLC13A2 promotes import of citrate into hepatocytes, serving as ...

Feb. 3, 2025 — Low-density lipoproteins (LDL) -- commonly known as bad cholesterol -- have long been on scientists' radar as a major contributor to heart disease. But these microscopic ...

They are also involved in tissue repair. Therefore, their dysfunction triggers various pathologies. Figure 1. Lipid metabolism in myeloid cells. Lipid homeostasis is regulated by the balance between ...

Lipid peroxides are oxidative degradation products of lipids, generated by a free radical chain reaction. Because of their abundance of reactive hydrogens, polyunsaturated fatty acids are highly ...

What can you do to help improve this project? It's not just about code: ...

You can use the Krita plugin with your custom installation of ComfyUI. When connecting it will check for a number of custom node extensions and models which it ...

Well, for one thing, your cholesterol levels could reach such stratospheric levels that lipids start oozing from your blood vessels, forming yellowish nodules on your skin. That was the disturbing ...

ACLY protein levels in scrambled shRNA or ACLY shRNA-transfected seminal vesicle epithelial ... (I) The glucose uptake ability of seminal vesicle epithelial cells was detected using ...

Lipids are hydrophobic or amphiphilic small molecules that include sterols, waxes, fatty acids and phospholipids, and are insoluble in water and soluble in organic solvent. Biological lipids are ...

LNPs are solid or semi-solid particles at room temperature. They are composed of a lipid core stabilized by surfactants or other agents. This lipid core provides a hydrophobic environment ideal for ...