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In particular, mitochondrial Ca 2+ plays a dual role: enabling physiological functions like metabolism and ATP synthesis while contributing to pathological processes such as apoptosis and ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ ...

Proteomic studies revealed that mitochondria contain ∼1,000 (in yeast ... proteins are the metabolite carriers such as the ADP and ATP carrier, and the phosphate carrier, which belong to ...

Therefore, optimizing hypoxanthine levels may help support dysfunctional mitochondria by introducing a metabolic shift away from the PPP. In summary, major ATP synthesis pathways are widely impaired ...

In particular, mitochondrial Ca 2+ plays a dual role: enabling physiological functions like metabolism and ATP synthesis while contributing to pathological processes such as apoptosis and ...

Figure 1: Mitochondrial involvement in cell death ... It contains the protein complexes from the electron transport chain, the ATP synthase and the adenine nucleotide translocator (ANT).

While MSCs predominantly utilize glycolysis in their native hypoxic niche within the bone marrow, new evidence reveals the importance of upregulation in mitochondrial activity in MSC function and ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial ...

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This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...