Esperion Therapeutics has two approved LDL-C lowering therapies, Nexletol and Nexlizet, but lacks a strong pipeline for future growth.

Data sources Seven databases were searched in December 2021. Eligibility criteria Observational or interventional studies with self-reported activity (including return to sport) or knee-related ...

and BMS-303141), BMS-303141 had the highest affinity for ACL and reduced ACL expression in the kidneys of db/db mice. We reported that BMS-303141 administration could decrease the levels of serum ...

It is a unique member of the plastic family as it can be broken down into its constituent units (or monomers) by PETases, which are enzymes that degrade PET. Until now, scientists have discovered ...

Engineered enzymes are poised to have transformative impacts across applications in energy, materials, biotechnology, and medicine. Recently, machine learning has emerged as a useful tool for ...

Rubisco is the enzyme responsible for carbon fixation in plants, algae and many bacteria. A screen of a comprehensive library of rubisco variants (each with a different single-amino-acid mutation ...

Temperature affects enzyme-catalysed reactions by influencing the rate at which they occur. For a reaction to occur between an enzyme and substrate the two molecules need to collide. At lower ...

The anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) are two major ligaments in the knee that work together to provide stability. They are also common sites of serious tears, ...

The key enzyme catalyzing cytosolic acetyl-CoA production is ACLY (16 ... or financial relationships that could be construed as a potential conflict of interest. ACC, acetyl-CoA carboxylase; ACLY, ATP ...