Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan ...

These functions are regulated by the interplay of various signaling pathways. The TGF-β and HIPPO pathways are particularly relevant due to their roles in tumor suppression and liver regulation.

View the Science Journal article. Our lab is currently working to develop methods to remove Hippo signaling using small molecules that may prove useful to treat human patients that have suffered heart ...

根据一项新的研究，Hippo信号通路（这是一种被认为在器官发育中发挥核心作用的基因程序）并未对蝇类和小鼠体内的正常 ...

Types of cell signalling pathways include checkpoint signalling, lipid signalling, growth signalling, nutrient signalling, insulin signalling, stress signalling, morphogen signalling, Hippo ...

更令人关注的是，研究中表明SLC35B2不仅是Hippo通路的新型转录靶基因，还在氧化应激状态下形成了一个正反馈循环，以进一步推动HCC的进展。这一发现为我们探讨肝细胞癌的潜在治疗靶点提供了新思路，尤其是在氧化应激背景下。