But, perhaps a more underrated pick for Spider-Man's greatest foe is the wonderfully complex Doctor Otto Octavius, aka Doctor Octopus. Peter Parker's personal life is constantly full of strife.

Following is a transcript of the video: Narrator: In the iconic bridge fight from "Spider-Man: No Way Home," Doctor Octopus' tentacles were the work of the visual effects team, but on set ...

This creative decision stands out particularly because Doctor Octopus has traditionally been one of Spider-Man’s earliest and most frequent adversaries across various media adaptations.