Here we review the B-1 subset of lymphocytes which produce self-reactive antibodies. By analyzing the IgM class of natural antibodies that recognize antigens from the nervous system, we emphasize ...

Lymphocytes are white blood cells that have ... PD-1 and CD73 regulates tolerance by restricting the expansion of auto-reactive CD4 + T cells independently of thymic selection.

Peripheral blood mononuclear cells (PBMCs) from healthy blood donor buffy coat were separated from 10 mL of whole blood on Ficoll-Hypaque density gradients, washed twice in phosphate buffered ...

Figure 1: IFN-γ capture assay enriches tumor-reactive T cells from immunized mice. Figure 3: IFN-γ capture assay detects and enriches tumor-specific T cells from human RCC. In conclusion ...

Aptamer-based T Lymphocyte Activity Screening and SEQuencing (ATLAS-seq), to better identify antigen-reactive T cells that are more likely to offer greater immune responses against cancer cells.