these RNAs all share the same basic single-stranded chemical structure with, in some cases, higher-order structures obtained through complementary base-pair folding. From the RNA Tie Club to today ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

The structure of NS5B significantly extends structural studies of RNA-dependent RNA polymerases ... changes that favor the correct incoming base recur in well-characterized polymerases, the ...

All five nucleobases that make up DNA and RNA have now been detected in meteorite samples, according to a study published yesterday (April 26) in Nature Communications. The work used recently ...

Researchers at Purdue University have developed NuFold, a machine learning tool that predicts 3D RNA structures from sequences. Dubbed the RNA equivalent of AlphaFold, NuFold bridges the gap in ...

Inosine can be incorporated into primers and probes as a universal base due to its ability to pair with multiple nucleotides ... and structural biology approaches will provide a more comprehensive ...

“A key feature of NuFold is how it represents RNA internally, considering the base pairs that are pivotal to the structure while accurately capturing RNA's inherent flexibility. In benchmark tests, ...

Both the sequence of bases and the three-dimensional structure of ... These RNA ranks are simple structures stabilized by the ...

Base editors designed to convert one DNA nucleotide to another may also perform large numbers of unwanted edits to RNA, according to a study published earlier this week (April 17) in Nature. Although ...

"A key feature of NuFold is how it represents RNA internally, considering the base pairs that are pivotal to the structure while accurately capturing RNA's inherent flexibility. In benchmark tests ...