DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...