Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type ...

The black circle you see in the middle of this image is one of many structures called central veins; they are located in liver lobules, large functional units within the liver. Here, you can see that ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

The downstream mechanisms by which endocrine disturbances cause liver disease might be similar to those involved in the development of primary liver disease. Hypothyroidism, for example ...

The finely balanced architecture of the liver lobules, in which the hepatocytes are arranged according to their different metabolic tasks, was completely disrupted without stellate cells.

The puzzle Starting with mouse livers treated with carbon tetrachloride (which models acetaminophen damage), Drasdo’s team built computational models of how liver lobules regenerate after damage.

The authors showed that at 24–48 h post-portal vein ligation, hepatocyte proliferation, indicated by Ki67-positive cells, was mainly seen distributed in zone 1 and zone 2 of liver lobules ...