A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

Researchers from Japan find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting ...

This work will be led by my graduate student, Douglas Guzior. Finally, we plan to use a new knockout mouse model we have established here at Michigan State University to further explore the ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

Baylor, together with Rice University, offers extensive resources dedicated to the molecular and phenotypic characterization of mouse models through its hosting of its Center for Precision Medicine ...