Medically reviewed by Jay N. Yepuri, MD Primary sclerosing cholangitis (PSC) is a progressive scarring of the liver's bile ducts. According to current estimates, between 5 and 16 in every 100,000 ...

Potential complications of bile duct scarring include bile duct infections (cholangitis), cirrhosis of the liver, and bile duct cancer. Often patients have no symptoms but abnormal liver chemistries ...

Primary sclerosing cholangitis (PSC) is a rare and chronic ... reporting early signs of PSC include fatigue, itching, jaundice, and abdominal pain. The symptoms worsen as the disorder progresses ...

The aims of palliation are the relief of jaundice and pruritis, prevention of recurrent cholangitis, and avoidance of hepatic failure due to unrelieved or progressive biliary obstruction.

Most patients present with painless jaundice. Less common symptoms include nonspecific abdominal pain, weight loss, and pruritis. Rarely, patients may present with cholangitis. [5] ...