These include DNA methyltransferase and histone deacetylase (HDAC) inhibitors. Further candidates, including inhibitors of acetyl-lysine readers (bromodomain-containing proteins), are undergoing ...

In this context, a comment by Chen et al. provides valuable insights into the catalytic and noncatalytic functions of the histone methyltransferase SETD2, a protein responsible for histone H3 ...

coli, demonstrating that it does, in fact, generate 4mC marks that could be detected using specific antibodies. Yushenova further demonstrated that bdelloids possess a histone methyltransferase that ...

More information: Maryam Kazerani et al, Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers, Proceedings of the National Academy ...