Nevertheless, this study shows that targeting fungal histone acetylation using nicotinamide — which is well tolerated in humans — or future fungal sirtuin inhibitors is a novel strategy to ...

Examples include DNA methylation and histone acetylation, which can turn genes on or off. Despite their differences, both mechanisms contribute to molecular aging. Researchers have long speculated ...

Histone post-translational modifications (PTMs) mediate the interplay between metabolism and epigenetics, influencing health and disease. Beyond acetylation, short-chain lysine acylations like ...