Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan ...

Since only a few PI5P4K regulators were known, the research team screened 29 other potential regulators and found two—core ...

It has long been understood that the Hippo pathway plays a critical role in the development of a wide range of diseases. Although once seen as an elusive pathway, emerging novel data and research ...

The Hippo pathway has been delineated during the past four years (for recent reviews, see refs 3–5).Although primarily worked out in Drosophila, homologues of the pathway components exist in ...

Sujata Rao, MD, Chief Medical Officer of Insilico Medicine As a potent pan-TEAD inhibitor, ISM6331 was developed to effectively restore the balance of the Hippo pathway and prevent the ...

A phase 3 trial of lanifibranor, a pan-PPAR agonist, in patients with MASH and liver fibrosis is ongoing. But with the 96.6 ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit ... to restrict cell proliferation and control heart size. Wild-type (left) and Hippo mutant (right) neonate mouse ...

The lab reported in the journal Science that a gene pathway called Hippo inhibits cardiac muscle regeneration during development. View the Science Journal article. Our lab is currently working to ...